Feeling of being keyed up or on edge
Feeling a lump in your throat
Being easily distracted
Trouble falling or staying asleep (insomnia)
Shortness of breath
If you have anxiety you may feel on edge about many or all aspects of your life. For example, you may feel intense worry about your safety or that of your loved ones, or you may feel that something bad is about to happen, even when there's no immediate danger. When you feel anxious, your body releases hormones that prepare you to react to a threat. This is called the fight-or-flight response. When anxiety gets out of control, this response can occur almost continuously, even at times when you seem calm.
Clinical Lab Assessments
Some of the following laboratory testing can provide information necessary for diagnosis and treatment. In addition, the tests listed may also give insight to functional metabolism and functional nutrient status in the body.
Adrenal Stress/Cortisol Testing/Neurotransmitter Testing: Adrenal insufficiency can lead to a host of problems, including a weakened immune response, anxiety and panic attacks. Imbalance in the Hypothalamic-Pituitary-Adrenal axis (HPA) is involved in anxiety related disorders. In this complex, adrenal functional abnormalities are relatively simple to identify and address. Plasma or salivary cortisol measurements can be used as a marker in the evaluation of stress syndromes that may relate to anxiety disorders. Some study has suggested that altered cortisol response to stress in panic disorders may complicate successful lifestyle intervention.
Elevation of thyroid antibodies has commonly been found in individuals with anxiety disorder. Correlations have been observed between thyroid laboratory values and anxiety. Assessment of thyroid hormone production, peripheral hormone conversion, cellular sensitivity response, thyroid hormone antibody activity can provide critical information for intervention with a goal of optimal function.
Allergy and Food Sensitivity Response Assessment
Allergic responses to foods, inhalants and environmental chemicals, and other substances can cause a variety of responses that induce or aggravate anxiety. Screening can enable an individual to eliminate or minimize exposure to unfriendly allergens.
Organic acids analysis is a useful method for measurement of biochemical intermediates in urine. These intermediates can offer information about key enzyme functions and nutrient competence (amino acids, nutrient cofactors, minerals, and fatty acids). Elevation of vanilmandelate reflects elevations in epinephrine and homovanillate indicates norepinephrine elevation. High levels of these neurotransmitters are associated with physiologic inability to manage stress.
Rule out Progesterone deficiency or Estrogen Dominance
Rule out Lyme Disease
Rule out Mycotoxins (Mold)
Rule out Pyroluria
Pyroluria is a known biochemical marker for life long anxiety symptoms. According to one alcoholism treatment center, one-third to one-half of alcoholics treated have this marker. High levels of pyrrolles systematically bind to B6 and zinc, preventing the use of these nutrients in the body and brain. The result is a myriad of symptoms, including severe inner tension, ongoing anxiety, poor stress control, fearfulness, and sometimes episodic anger.
Obtain Magnesium Levels via RBC erthrocyte assessement
Rule out Mercury Toxicity
Deficiencies or imbalances in amino acids can indicate fundamental reasons for numerous disorders. Amino acid malabsorption syndrome or imbalanced amino patterns reflect abnormal organ and glandular processes that have critical bearing on optimal function. Phenylalanine and tyrosine are precursors to the catecholamines and affect the capability to manage stress in anxiety disorders.
Conventional Medical Approach
Prescription drug treatment includes anti-anxiety agents such as lorazepam (Ativan), alprazolam (Xanax), and buspirone (Buspar). Antidepressants, such as fluoxetine (Prozac), paroxetine (Paxil), and venlafaxine (Effexor), are often prescribed to treat generalized anxiety and panic attacks.
Magnesium may provide benefit for people with anxiety. Symptoms of magnesium deficiency include anxiety, nervousness, insomnia, muscle fatigue, and tachycardia. Clinical studies have supported the theory that anxiety is one of the symptoms that can occur in individuals with magnesium depletion.
In a study of individuals suffering from frequent anxiety attacks, patients were given vitamin B6 (125mg, 3 times daily) and tryptophan (2 grams daily). This regime enabled in 70 percent of patients (9 of 13) to become free of anxiety attacks within three weeks. Vitamin B6 is required for the conversion of tryptophan to serotonin. Therefore, a deficiency of vitamin B6 may result in symptoms of anxiety and depression due to inhibition of serotonin synthesis. In a study of individuals suffering from frequent anxiety attacks, patients were given vitamin B6 (125mg, 3 times daily) and tryptophan (2 grams daily). This regime enabled in 70 percent of patients (9 of 13) to become free of anxiety attacks within three weeks.
Clinical studies have found that inositol may be a valuable natural aid for patients suffering with Panic Attacks and may provide benefit for anxiety suffers. Biochemically, inositol is precursor for the phosphatidyl-inositol system and as such should be considered for its impact on elevated cortisol levels.
A double-blind, controlled study comparing the effect of inositol against fluvoxamine in panic disorder. Twenty patients completed 1 month of inositol up to 18 g/day and 1 month of fluvoxamine (Luvox) up to 150 mg/day. Improvements on Hamilton Rating Scale for Anxiety scores were similar for both treatments. In the first month, inositol reduced the number of panic attacks per week by 4.0 compared with a reduction of 2.4 (2) with fluvoxamine.
Studies that induce low levels of tryptophan result in low serotonin levels, which can cause anxiety. Tryptophan and 5-hydroxytryptophan (5-HTP) are the precursors for serotonin. Tryptophan is an essential amino acid that the body cannot manufacturer. Tryptophan is converted into 5-HTP, which in turn is converted into serotonin. There is ample evidence that tryptophan depletion causes reduced synthesis of serotonin, which can result in anxiety and other mood disorders.
Patients taking anti-anxiety drugs or other antidepressants should not take tryptophan or 5-HTP without the supervision of a health care professional because it can increase the effects of other antidepressants.
Tyrosine is the precursor to the neurotransmitters dopamine, norepinephrine, and epinephrine, which all influence and regulate mental and emotional states. In a clinical study reduced brain tyrosine levels caused a reduction in catecholamine synthesis. This caused decreased calmness, increased tension and anger. The authors of this study state that brain catecholaminergic dysregulation is involved in pathological anxiety states.
Phosphorylated Serine: should be considered with elevated cortisol levels
Several plants, known as nervines (nerve tonics), are used in traditional herbal medicine for people with anxiety, with few reports of toxicity. Most nervines have not been rigorously investigated by scientific means to confirm their efficacy. However, one study found that a combination of the nervines valerian and passion flower reduced symptoms in people suffering from anxiety. In a double-blind study, 45 drops per day of an extract of passion flower taken for four weeks was as effective as 30 mg per day of oxazepam (Serax), a medication used for anxiety.
Passionflower has been reported to have sedative, hypnotic, antispasmodic properties. In humans, passionflower has been reported effective when used in combination with other sedative and anti-anxiety herbs such as valerian.
Valerian has long been used as an agent to soothe the nervous system in response to stress. It has been reported that valerian helps improve sleep quality.
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Compliments of Functional Medicine University (Dr Ron Grisanti) - www.funtionalmedicineuniversity.com